Superchips Cortex ?
 

Anyone here had any experience with these chips, i'm looking to chip a 2001 LB7 Dually truck and i was wondering if this would seem like a good idea...

The truck is a friend of mines and he's already straight piped it so EGTs should be on the down low :)

they say it makes 425hp, is that safe on the tranny and is there a relearn option ?

I'd say NO. There's better tuners out there... But anything that's much more than 75hp over stock will start killing the trans.

Thats a bit much for that tranny. I would go with a mild tune of any tuner. I havent tried the Superchips so I can't compare but If you can find a PPE or a Edge with the insight I would do that first. Prolly lots out there used for cheap...